Cancer Research UK Cambridge Institute
We are seeking a talented Bioinformatician to join the Spatial Profiling and Annotation Centre of Excellence (SPACE), led by Prof. Gregory Hannon and Dr. Dario Bressan, at the CRUK Cambridge Institute, University of Cambridge. This role involves analysing and integrating single-cell and spatial transcriptomic and proteomic data across various cancer types, with the goal to understand how a tumour's spatial organization influences its progression, dissemination, and response to therapy.
The SPACE centre of excellence is a multidisciplinary group focused on improving spatial molecular profiling technologies (spatial proteomics, transcriptomics, genomics) and applying them to big problems in cancer biology and beyond, through large collaborations within and outside of Cambridge. It includes most available spatial omics technologies under one roof, as well as a world class data processing centre and a dedicated staff including biologists, technologists and bioinformaticians. The centre was developed following a successful cancer grand challenge project (IMAXT). Some of the projects currently carried out in the centre include the development of a predictor for triple-negative breast cancer response to therapy, work on the impact of ovarian cancer tumour heterogeneity on its metastatic dissemination, and a project focused on investigating low-to-high grade transition in gliomas.