Department of Clinical Neurosciences

The University of Cambridge wishes to appoint a talented postdoctoral research associate to join the research group of Prof Rita Horvath at the Department of Clinical Neurosciences and the John Van Geest Brain Repair Centre.

The position is part of a research grant from the joint call of the Action Medical Research and Action for AT, to characterise novel biomarkers of ataxia telangiectasia that support monitoring neurological progression and measuring treatment effect. The focus of your work will be to study how neuron-specific biomarkers reflect the progression of ataxia and how these change on treatment with novel antisense oligonucleotides.

You will use cutting-edge technologies, including functional studies on neuronal stem cells and human neurons. Proteomics, RNA sequencing and other omics technologies will be performed to identify the molecular mechanism of neurodegeneration and ataxia in children and adults. The over-arching aim of the research group is to develop new treatments for mitochondrial diseases and other inherited rare neuromuscular diseases using a combination of genomic, cell biology and specialized assays. You will have access to a team of experienced bioinformaticians, but have the opportunity to be trained and perform independent in-depth bioinformatic analysis of large datasets. You will have access to clinical samples from the MitoCamb neurogenetics clinic, to apply and translate novel technology and insights towards a human disease context. 

https://www.cam.ac.uk/jobs/postdoctoral-research-associate-fixed-term-rr51412