Department of Clinical Neurosciences

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced pluripotent stem cell (iPS) derived cells. The project will utilize CRISPR-Cas9 technology and other gene editing tool to achieve precise and targeted modifications of iPS-derived cells, specifically microglia and neurons. The primary aim will be the validation of new experimental targets to modulate neuro-immune interactions and halt chronic neuroinflammation. This project is part of a bigger effort aimed at modulating metabolic pathways in microglia to stop secondary neuronal damage and prevent cognitive decline (sponsor: MRC).

The ideal candidate should have: - PhD in Cell Biology, Molecular Biology, or a related field. - Strong background in CRISPR-Cas9 technology, gene editing, and lentiviral vectors production. - Expertise in cell culture techniques, including experience with human iPS cells (ideally iPS-derived microglia and neurons). - Excellent data analysis and interpretation skills. - Strong written and oral communication skills. - Ability to work independently and as part of a team.

Additional Desirable Skills: - Understanding of cell metabolism and metabolic pathways. - Knowledge of bioinformatics and computational biology. - Experience with single-cell omics technologies. - Familiarity with databases and software for bioinformatics analyses.

https://www.cam.ac.uk/jobs/postdoctoral-research-associate-fixed-term-rr48525